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    Input

    OpenFold3 InputsChoose an example to get started.
    Binder Design Amino acid sequence input selection
    Binder Design Amino acid sequence input selection
    Choose which cached model you want to use for this blueprint
    Amino Acid Sequence
    Amino Acid Sequence
    For interactivity, the sequence of the target protein cannot be edited, but stay tuned
    RFDiffusion InputsComplete this form to generate a Protein file that will be used in ProteinMPNN in this Blueprint.

    PDB Generated by OpenFold3

    PDB Generated by OpenFold3

    contigs stands for contiguous [protein regions].

    contigs stands for contiguous [protein regions].

    The hotspot residues string provides a way to specify which region the new protein (binder) must contact with the original input protein (a target), therefore we can guide a binder to a specific region.

    The hotspot residues string provides a way to specify which region the new protein (binder) must contact with the original input protein (a target), therefore we can guide a binder to a specific region.

    The diffusion steps parameter tells RFdiffusion how many steps it will run the denoising process for. 15 is the minimum.

    1520253035404550
    ProteinMPNN InputsChoose how the protein target will be sent to ProteinMPNN.

    PDB Generated by RF Diffusion

    PDB Generated by RF Diffusion

    Chose a model option
    Chose a model option

    Select Sampling Temperature

    0.010.110.210.310.410.510.610.710.810.911
    Free APIs for development
    Your API requests may be rate limited. Traffic from other users may cause throttling.
    Coming Soon!

    GOVERNING HOSTING TERMS: Use of this trial service is governed by the NVIDIA API Trial Terms of Service. Use of this blueprint software is governed by the Apache 2.0, and enables use of separate open source and proprietary software, models, data and services governed by their respective licenses below:
    1. Use of the RfDiffusion NIM is governed by the NVIDIA Software License Agreement and Product-Specific Terms for AI Products. Use of the model is governed by the NVIDIA AI Foundation Models Community License Agreement. Additional Information: BSD license.
    2. Use of the ProteinMPNN NIM is governed by the NVIDIA Software License Agreement and Product-Specific Terms for NVIDIA AI Products. Use of the model is governed by the NVIDIA Community Model License. ADDITIONAL INFORMATION: MIT License.
    3. Use of the OpenFold3 NIM is governed by the NVIDIA Software License Agreement and Product-Specific Terms for NVIDIA AI Products. Use of the model is governed by the NVIDIA Open Model License. ADDITIONAL INFORMATION: Apache 2.0.

    Output

    Click Design ProteinAdjust the settings and click Design Protein to see your outcome here.

    nvidia

    Build A Generative Protein Binder Design Pipeline

    Enterprise

    This blueprint shows how generative AI and accelerated NIM microservices can design protein binders smarter and faster.

    rfdiffusion•proteinmpnn•openfold3
    • BioNemo
    • Biology
    • Protein Generation
    • NVIDIA BioNemo
    • Healthcare & Life Sciences
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