NVIDIA
Explore
Models
Blueprints
GPUs
Docs
⌘KCtrl+K
View All Playbooks
View All Playbooks

onboarding

  • Set Up Local Network Access
  • Open WebUI with Ollama

data science

  • Single-cell RNA Sequencing
  • Portfolio Optimization
  • CUDA-X Data Science
  • Text to Knowledge Graph
  • Optimized JAX

tools

  • DGX Dashboard
  • Comfy UI
  • RAG Application in AI Workbench
  • Set up Tailscale on Your Spark
  • VS Code
  • Connect Three DGX Spark in a Ring Topology
  • Connect Multiple DGX Spark through a Switch

fine tuning

  • FLUX.1 Dreambooth LoRA Fine-tuning
  • LLaMA Factory
  • Fine-tune with NeMo
  • Fine-tune with Pytorch
  • Unsloth on DGX Spark

use case

  • NemoClaw with Nemotron 3 Super and Telegram on DGX Spark
  • cuTile Kernels
  • CLI Coding Agent
  • Live VLM WebUI
  • Install and Use Isaac Sim and Isaac Lab
  • Vibe Coding in VS Code
  • Build and Deploy a Multi-Agent Chatbot
  • Connect Two Sparks
  • NCCL for Two Sparks
  • Build a Video Search and Summarization (VSS) Agent
  • Spark & Reachy Photo Booth
  • Secure Long Running AI Agents with OpenShell on DGX Spark
  • OpenClaw 🦞

inference

  • LM Studio on DGX Spark
  • Speculative Decoding
  • Run models with llama.cpp on DGX Spark
  • Nemotron-3-Nano with llama.cpp
  • SGLang for Inference
  • TRT LLM for Inference
  • NVFP4 Quantization
  • Multi-modal Inference
  • NIM on Spark
  • vLLM for Inference

Single-cell RNA Sequencing

15 MIN

An end-to-end GPU-powered workflow for scRNA-seq using RAPIDS

data science
View on GitHub
OverviewOverviewInstructionsInstructionsTroubleshootingTroubleshooting
SymptomCauseFix
Docker is not found.Docker may have been uninstalled, as it is preinstalled on your DGX SparkPlease install Docker using their convenience script here: curl -fsSL https://get.docker.com -o get-docker.sh && sudo sh get-docker.sh. You will be prompted for your password.
Docker command unexpectedly exits with "permissions" errorYour user is not part of the docker groupOpen Terminal and run these commands: sudo groupadd docker && sudo usermod -aG docker $USER. You will be prompted for your password. Then, close the Terminal, open a new one, and try again
Docker container download, environment build, or data download failsThere was either a connectivity issue or a resource may be temporarily unavailable.You may need to try again later. If this persists, please post on the Spark user forum for support

NOTE

DGX Spark uses a Unified Memory Architecture (UMA), which enables dynamic memory sharing between the GPU and CPU. With many applications still updating to take advantage of UMA, you may encounter memory issues even when within the memory capacity of DGX Spark. If that happens, manually flush the buffer cache with:

sudo sh -c 'sync; echo 3 > /proc/sys/vm/drop_caches'

For latest known issues, please review the DGX Spark User Guide.

Resources

  • DGX Spark Documentation
  • DGX Spark Forum
  • DGX Spark User Performance Guide
Terms of Use
Privacy Policy
Your Privacy Choices
Contact

Copyright © 2026 NVIDIA Corporation