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    onboarding

    • Set Up Local Network Access
    • Open WebUI with Ollama

    data science

    • Single-cell RNA Sequencing
    • Portfolio Optimization
    • CUDA-X Data Science
    • Build Knowledge Graphs with txt2kg
    • Optimized JAX

    tools

    • DGX Dashboard
    • RAG Application in AI Workbench
    • Set up Tailscale on Your Spark
    • VS Code
    • Connect Three DGX Spark in a Ring Topology
    • Connect Multiple DGX Spark through a Switch

    fine tuning

    • FLUX.1 Dreambooth LoRA Fine-tuning
    • LLaMA Factory
    • Fine-tune with NeMo
    • Fine-tune with Pytorch
    • Unsloth on DGX Spark

    use case

    • Run Hermes Agent with a Local LLM
    • cuTile Kernels
    • CLI Coding Agent
    • Run NemoClaw with a Local LLM
    • 🦞 Set Up Example NemoClaw Agents 🦞
    • Live VLM WebUI
    • Install and Use Isaac Sim and Isaac Lab
    • Vibe Coding in VS Code
    • Build and Deploy a Multi-Agent Chatbot
    • Connect Two Sparks
    • NCCL for Multiple Sparks
    • Build a Video Search and Summarization (VSS) Agent
    • Spark & Reachy Photo Booth
    • Secure AI Agents with OpenShell
    • Run OpenClaw with a Local LLM

    inference

    • Generate Images and Videos with ComfyUI
    • Serve LLMs with vLLM
    • Speculative Decoding
    • Run models with llama.cpp on DGX Spark
    • Nemotron Model Family on DGX Spark
    • Serve LLMs with SGLang
    • TRT LLM for Inference
    • Quantize Models to NVFP4 with NVIDIA Model Optimizer
    • Multi-modal Inference
    • NIM on Spark
    • LM Studio on DGX Spark

    Single-cell RNA Sequencing

    15 MIN

    An end-to-end GPU-powered workflow for scRNA-seq using RAPIDS

    • data science
    View on GitHub
    OverviewOverviewInstructionsInstructionsTroubleshootingTroubleshooting
    SymptomCauseFix
    Docker is not found.Docker may have been uninstalled, as it is preinstalled on your DGX SparkPlease install Docker using their convenience script here: curl -fsSL https://get.docker.com -o get-docker.sh && sudo sh get-docker.sh. You will be prompted for your password.
    Docker command unexpectedly exits with "permissions" errorYour user is not part of the docker groupOpen Terminal and run these commands: sudo groupadd docker && sudo usermod -aG docker $USER. You will be prompted for your password. Then, close the Terminal, open a new one, and try again
    Docker container download, environment build, or data download failsThere was either a connectivity issue or a resource may be temporarily unavailable.You may need to try again later. If this persists, please post on the Spark user forum for support

    NOTE

    DGX Spark uses a Unified Memory Architecture (UMA), which enables dynamic memory sharing between the GPU and CPU. With many applications still updating to take advantage of UMA, you may encounter memory issues even when within the memory capacity of DGX Spark. If that happens, manually flush the buffer cache with:

    sudo sh -c 'sync; echo 3 > /proc/sys/vm/drop_caches'

    For latest known issues, please review the DGX Spark User Guide.

    Resources

    • DGX Spark Documentation
    • DGX Spark Forum
    • DGX Spark User Performance Guide
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